Cuyahoga County, Ohio Business Directory & Community Resources
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View the 2025 U.S. Census demographic profile for Cuyahoga County
Cuyahoga County — County Seat: Cleveland
2026 Population Estimate: 1,232,236 | Official Website: https://cuyahogacounty.gov/
Cuyahoga County is Ohio's second most populous county and the heart of Greater Cleveland. Home to 58 municipalities including the City of Cleveland — Ohio's second-largest city — and some of the region's most affluent suburbs, the county is a major national center for healthcare, culture, and higher education. The Cleveland Clinic is consistently ranked among the top hospitals in the world, and the broader healthcare and bioscience sector is the county's dominant employer. World-class cultural institutions include the Rock and Roll Hall of Fame, the Cleveland Museum of Art (free general admission), Playhouse Square (the largest performing arts center outside New York City), and University Circle. Major corporate presences include Cleveland-Cliffs, KeyCorp, Sherwin-Williams, and Parker Hannifin. The county is served by the Cleveland Metroparks system — the legendary "Emerald Necklace" — and is home to the Cleveland Guardians, Cleveland Cavaliers, and Cleveland Browns.
▸ Key Industries & Major Employers
Healthcare, financial services, advanced manufacturing, legal services, and technology.
Ohio's second most populous county is home to the Cleveland Clinic (one of the top-rated hospital systems in the world), University Hospitals, KeyCorp, Sherwin-Williams (global headquarters), Progressive Insurance, Eaton Corporation, Parker Hannifin, and dozens of Fortune 500 companies. Cleveland State, Case Western Reserve, and John Carroll University anchor higher education.
▸ Notable Economic Development Initiatives
REDI's northeast partner Team NEO coordinates regional economic strategy. Sherwin-Williams' $600M downtown Cleveland global headquarters, completed in 2024, is a landmark anchor for downtown revitalization. Greater Cleveland Partnership drives business retention. The Cuyahoga County Department of Development administered $3.47M in Economic Impact Grants to 13 communities in 2025. The county leads the state in brownfield remediation activity.
▸ Infrastructure & Investment Highlights
I-90, I-77, I-480, I-490, and I-71 provide comprehensive highway coverage. Cleveland Hopkins International Airport (CLE) offers direct domestic and international service. The Port of Cleveland handles approximately 13 million tons annually. A major shoreline improvement project along the Cuyahoga River continues to attract mixed-use redevelopment.
